Single-cell atlas of human variation in hematopoietic tissue

Work Group

Project Lead(s)

Project Status


Project Deliverables

Processing, analysis, annotation, visualization, and exploration of a large single-cell hematopoiesis reference dataset


HMS Department

Systems Biology

Project Description

CCB worked with Dr. Klein lab on a molecular atlas of hematopoiesis in human bone marrow. As part of a deeper molecular characterization of cell fate and differentiation during hematopoiesis, the Klein Lab aimed to profile 100 bone marrow samples via 10x Genomics single-cell RNA-sequencing (scRNA-seq).